Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)


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Efficacy of Novel Acid Buffering Vaginal Tablet of Metronidazole for Bacterial Vaginosis

Author(s): Patel Geeta M, Patel Madhabhai M

Email(s): geekhappy2002@yahoo.co.in

DOI: Not Available

Address: Patel Geeta M1* and Patel Madhabhai M2
1Department of Pharmaceutics and Pharmaceutical Technology, S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva-382711. Gujarat, India.
2Kalol Institute of Pharmacy, Kalol, Gujarat, India
*Corresponding Author

Published In:   Volume - 1,      Issue - 3,     Year - 2009

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ABSTRACT:
To develop more effective treatment for bacterial vaginosis, metronidazole was formulated in acid buffering bioadhesive tablet formulations that increase the time of contact of drug with the vaginal mucosa. Oral metronidazole is still the drug of choice in the treatment of bacterial vaginosis. Yet, side effects have been reported, and dosage as well as duration of therapy is still controversial. This study presents a possible alternative treatment using a single dose of metronidazole administered in a vaginal bioadhesive table. Double blind, randomized, clinical trials with 24 patients was carried out. The cure rate in acid buffering bioadhesive metronidazole vaginal tablet group was higher (86.66%) than metronidazole vaginal tablet (60%). No side effects were reported. Treatment of bacterial vaginosis with a single application of metronidazole in a bioadhesive vaginal tablet was found to be a valid alternative. These results indicate that a new bioadhesive vaginal tablet formulations might be further developed for safe convenient and effective treatment of bacterial vaginosis.


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Cite this article:
Patel Geeta M, Patel Madhabhai M. Efficacy of Novel Acid Buffering Vaginal Tablet of Metronidazole for Bacterial Vaginosis. Research J. Pharma. Dosage Forms and Tech. 2009; 1(3):188 - 190.

Cite(Electronic):
Patel Geeta M, Patel Madhabhai M. Efficacy of Novel Acid Buffering Vaginal Tablet of Metronidazole for Bacterial Vaginosis. Research J. Pharma. Dosage Forms and Tech. 2009; 1(3):188 - 190.   Available on: https://www.rjpdft.com/AbstractView.aspx?PID=2009-1-3-4


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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

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DOI: 10.5958/0975-4377 

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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. The aim of RJPDFT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPDFT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical Chemistry, Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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