Author(s):
Dhananjay A. Deore, Shivraj P. Jadhav, Sunil K. Mahajan
Email(s):
deored680@gmail.com
DOI:
10.52711/0975-4377.2026.00053 
Address:
Dhananjay A. Deore1*, Shivraj P. Jadhav1, Sunil K. Mahajan2
1Department of Pharmaceutics, Divine College of Pharmacy, Satana, India. Savitribai Phule Pune University, Pune, 423301, Maharashtra, India.
2Department of Pharmaceutical Chemistry, Divine College of Pharmacy, Satana, India. Savitribai Phule Pune University, Pune, 423301, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 4,
Year - 2026
ABSTRACT:
Exosomes are naturally occurring nanovesicles (30–150nm) that serve as biological carriers for the targeted delivery of medicinal substances. Their membrane composition facilitates passage over physiological barriers, such as the blood-brain barrier, and offers good compatibility with bodily tissues. Using methods like electroporation, incubation, and donor-cell modification, therapeutic substances including medications, proteins, and genetic elements can be integrated into these vesicles. Selective contact with sick cells is enhanced by surface functionalization. By improving targeted medication delivery and lowering undesirable systemic exposure, these vesicles have demonstrated promise uses in the treatment of neurological diseases and cancer. Particle size, zeta potential, encapsulation efficiency, release kinetics, cellular uptake, stability, and targeting capability are all evaluated when characterizing exosome formulations. Notwithstanding these benefits, a number of challenges still exist, such as inconsistent isolation protocols, low loading efficiency, instability associated with storage, and challenges in large-scale production. Future applications of vesicle engineering and manufacturing technologies in precision-focused medicinal delivery systems may benefit from ongoing advancements in these fields.
Cite this article:
Dhananjay A. Deore, Shivraj P. Jadhav, Sunil K. Mahajan. Exosome-Based Targeted Drug Delivery Systems: Current Advances and Challenges. Research Journal of Pharmaceutical Dosage Forms and Technology. 2026; 18(4):383-9. doi: 10.52711/0975-4377.2026.00053
Cite(Electronic):
Dhananjay A. Deore, Shivraj P. Jadhav, Sunil K. Mahajan. Exosome-Based Targeted Drug Delivery Systems: Current Advances and Challenges. Research Journal of Pharmaceutical Dosage Forms and Technology. 2026; 18(4):383-9. doi: 10.52711/0975-4377.2026.00053 Available on: https://www.rjpdft.com/AbstractView.aspx?PID=2026-18-4-15
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