Author(s):
Pushpendra Kumar Sahu, Shadaan Ali, Digeshwari Patel, Anish Chandy
Email(s):
anishc@cecbilaspur.ac.in
DOI:
10.52711/0975-4377.2026.00047 
Address:
Pushpendra Kumar Sahu1, Shadaan Ali1, Digeshwari Patel2, Anish Chandy3
1Students, School of Pharmacy, Chouksey Engineering College, Bilaspur, Chhattisgarh, India.
2Assistant Professor, School of Pharmacy, Chouksey Engineering College, Bilaspur, Chhattisgarh, India.
3Associate Professor, School of Pharmacy, Chouksey Engineering College, Bilaspur, Chhattisgarh, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 4,
Year - 2026
ABSTRACT:
Hydrogels are more advantageous owing to their favorable physical properties as compared to the traditional dosage forms which enhances the delivery of antifungal drug into the skin. Therefore, the current study aims at overcoming the solubility challenges posed by a hydrophobic antifungal drug, clotrimazole by embedding it into a hydrogel matrix. The objective of the current study was to come up with a pregelled hydrogel having 1% w/w clotrimazole through the use of water-soluble co-solvents such as glycerin and polyethylene glycol. Carbomer was the gelling agent used in varying concentrations. The stability, drug release, spreadability, pH, viscosity and drug content of the formulations were studied. A spectrophotometer methodology was employed to analyze the clotrimazole present in the formulations. It was found that the drug release was highest in the F4 formulation that has 0.4g of carbomer thereby making it the optimized formulation.
Cite this article:
Pushpendra Kumar Sahu, Shadaan Ali, Digeshwari Patel, Anish Chandy. Formulation and Evaluation of Clotrimazole Polymer Based Hydrogel for Antifungal Therapy. Research Journal of Pharmaceutical Dosage Forms and Technology. 2026; 18(4):339-4. doi: 10.52711/0975-4377.2026.00047
Cite(Electronic):
Pushpendra Kumar Sahu, Shadaan Ali, Digeshwari Patel, Anish Chandy. Formulation and Evaluation of Clotrimazole Polymer Based Hydrogel for Antifungal Therapy. Research Journal of Pharmaceutical Dosage Forms and Technology. 2026; 18(4):339-4. doi: 10.52711/0975-4377.2026.00047 Available on: https://www.rjpdft.com/AbstractView.aspx?PID=2026-18-4-9
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