ABSTRACT:
Nanosponges are novel nanosized porous carriers widely explored in pharmaceutical sciences for controlled and targeted drug delivery. Their unique porous structure enables encapsulation of both hydrophilic and hydrophobic drugs, improving solubility, stability, bioavailability, and therapeutic efficacy. Nanosponges are mainly prepared using cyclodextrins and suitable cross-linking agents, forming stable three-dimensional networks capable of sustained drug release. These systems have attracted significant attention in the treatment of acne, cancer, fungal infections, and topical disorders due to reduced toxicity and improved site-specific action. The present review summarizes the structure, composition, methods of preparation, characterization, advantages, disadvantages, and pharmaceutical applications of nanosponges. Recent advances, safety aspects, evaluation parameters, and future perspectives are also discussed. Due to their versatile nature and controlled release behavior, nanosponges represent an emerging platform in modern targeted drug delivery systems.
Cite this article:
Vinod Matole, Pranita Kokare. Nanosponges: Emerging Carrier for Targeted Drug Delivery. Research Journal of Pharmaceutical Dosage Forms and Technology.2026; 18(3):252-4. doi: 10.52711/0975-4377.2026.00036
Cite(Electronic):
Vinod Matole, Pranita Kokare. Nanosponges: Emerging Carrier for Targeted Drug Delivery. Research Journal of Pharmaceutical Dosage Forms and Technology.2026; 18(3):252-4. doi: 10.52711/0975-4377.2026.00036 Available on: https://www.rjpdft.com/AbstractView.aspx?PID=2026-18-3-11
REFERENCES:
1. Selvamuthukumar S, Anandam S, Krishnamoorthy K. Nanosponges: A novel class of drug delivery system. J Pharm Pharm Sci. 2012; 15(1): 103-111.
2. Iravani S, Varma RS. Nanosponges for drug delivery and cancer therapy: Recent advances. Nanomaterials. 2022; 12(14): 2440. doi:10.3390/nano12142440.
3. Agrawal R, et al. Nanosponge: A promising strategy in pharmaceutical science. Heliyon. 2024; 10: e23303. doi:10.1016/j.heliyon.2023.e23303.
4. Ankem B, Tejaswi SK. Nanosponges – A revolutionary drug delivery carrier. Asian J Pharm Clin Res. 2023; 16(4): 20-28.
5. Sehgal N, Gupta V. A review on nanosponges for anticancer drug delivery. Asian J Pharm Clin Res. 2019; 12(7): 15-24.
6. Bhowmik H, et al. Nanosponges: A review. Int J Appl Pharm. 2018; 10(4): 1-7.
7. Nanosponges in therapeutics: Current advancements and future directions. J Drug Deliv Sci Technol. 2024; 101: 106258. doi:10.1016/j.jddst.2024.106258.
8. Nitish, Jeganath S. Nanosponges – A promising novel drug delivery system. Res J Pharm Technol. 2021; 14(1): 501-505. doi:10.5958/0974-360X.2021.00089.3.
9. Patel EK, Oswal RJ. Nanosponge and microsponges: A novel drug delivery system. Int J Res Pharm Biomed Sci. 2012; 3(1): 237-244.
10. Swaminathan S, Vavia PR, Trotta F. Cyclodextrin-based nanosponges encapsulating anticancer drugs. Int J Pharm. 2013; 454(1): 59-66. doi:10.1016/j.ijpharm.2013.06.062.