Author(s):
Ram Sukhdev Khandagale, R. S. Radke, R. R. Pagore, K. R. Biyani
Email(s):
ramkhandagale007@gmail.com
DOI:
10.52711/0975-4377.2026.00045 
Address:
Ram Sukhdev Khandagale1*, R. S. Radke1, R. R. Pagore1, K. R. Biyani2
1*Karmayogi Tatyasaheb Bondre Institute of Pharmacy, Chikhli, Dist. Buldhana, Maharashtra (India) - 443201.
2Anuradha College of Pharmacy, Chikhli, Dist. Buldhana, Maharashtra (India) - 443201.
*Corresponding Author
Published In:
Volume - 18,
Issue - 4,
Year - 2026
ABSTRACT:
The present study was focused on the formulation and evaluation of Ketoprofen transdermal patches using Chitosan and Carbopol 934 polymers by solvent casting technique for sustained drug delivery. A total of six formulations (F1–F6) were prepared using different ratios of Chitosan and Carbopol 934 and evaluated for various physicochemical parameters such as physical appearance, thickness, weight variation, drug content, folding endurance, surface pH, moisture uptake, swelling index, and in-vitro drug release study. All the prepared patches showed smooth appearance, flexibility, and acceptable physicochemical properties. Among all formulations, batch F4 showed better results with thickness of 0.30±0.01mm, drug content of 99.12±0.22%, folding endurance of 296±3, surface pH of 6.8±0.1, and swelling index of 91.8±1.3%. In-vitro drug release study showed that formulation F4 provided sustained drug release up to 12hours with cumulative drug release of 97.24±0.90%. Stability studies of optimized formulation F4 were carried out for 90 days under accelerated conditions and the formulation remained stable without significant changes in drug content, folding endurance, and drug release profile. From the overall findings, it was concluded that Ketoprofen transdermal patches prepared using Chitosan and Carbopol 934 can be considered a suitable and effective sustained release transdermal drug delivery system.
Cite this article:
Ram Sukhdev Khandagale, R. S. Radke, R. R. Pagore, K. R. Biyani. Preparation and In Vitro Assessment of Ketoprofen Transdermal Drug Delivery Systems. Research Journal of Pharmaceutical Dosage Forms and Technology. 2026; 18(4):325-0. doi: 10.52711/0975-4377.2026.00045
Cite(Electronic):
Ram Sukhdev Khandagale, R. S. Radke, R. R. Pagore, K. R. Biyani. Preparation and In Vitro Assessment of Ketoprofen Transdermal Drug Delivery Systems. Research Journal of Pharmaceutical Dosage Forms and Technology. 2026; 18(4):325-0. doi: 10.52711/0975-4377.2026.00045 Available on: https://www.rjpdft.com/AbstractView.aspx?PID=2026-18-4-7
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