Author(s):
Gitanjali Dipesh Sonis, Mansi Amitkumar Dhankani, Amitkumar Rajkumar Dhankani, Sunil Pandit Pawar
Email(s):
gitusonis2@gmail.com
DOI:
10.52711/0975-4377.2026.00033 
Address:
Gitanjali Dipesh Sonis, Mansi Amitkumar Dhankani, Amitkumar Rajkumar Dhankani, Sunil Pandit Pawar
Department of Pharmaceutics, P.S.G.V.P. Mandal’s College of Pharmacy, Shahada, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 3,
Year - 2026
ABSTRACT:
Transethosomal gel represents an advanced vesicular drug delivery system composed of phospholipids, ethanol, and edge activators, developed to enhance drug permeation across the skin and prolong residence time, thereby improving therapeutic effectiveness. Compared to conventional vesicular carriers such as liposomes and ethosomes, transethosomes demonstrate superior stability, elasticity, and deformability. Their nanoscale vesicle size and high flexibility enable structural adaptation, facilitating efficient penetration through the various layers of the skin. The combined presence of ethanol and edge activators imparts softness and elasticity to the vesicular membrane, promoting enhanced drug transport into systemic circulation. Several formulation techniques are employed in the preparation of transethosomes, including the cold method, hot method, thin-film hydration method, and mechanical dispersion method. Evaluation of transethosomal formulations involves assessment of vesicle size, surface charge, entrapment efficiency, surface morphology, drug–excipient compatibility, drug content, and stability. Transethosomal systems have been widely investigated for the delivery of NSAIDs, hormones, antibiotics, antifungal agents, anti-parkinsonian drugs, and cosmeceuticals. Owing to their enhanced permeation efficiency and improved therapeutic performance, transethosomal gels exhibit high patient compliance.
Cite this article:
Gitanjali Dipesh Sonis, Mansi Amitkumar Dhankani, Amitkumar Rajkumar Dhankani, Sunil Pandit Pawar. Transethosomal Gel as A Promising Nanocarrier for Skin Drug Delivery. Research Journal of Pharmaceutical Dosage Forms and Technology.2026; 18(3):227-2. doi: 10.52711/0975-4377.2026.00033
Cite(Electronic):
Gitanjali Dipesh Sonis, Mansi Amitkumar Dhankani, Amitkumar Rajkumar Dhankani, Sunil Pandit Pawar. Transethosomal Gel as A Promising Nanocarrier for Skin Drug Delivery. Research Journal of Pharmaceutical Dosage Forms and Technology.2026; 18(3):227-2. doi: 10.52711/0975-4377.2026.00033 Available on: https://www.rjpdft.com/AbstractView.aspx?PID=2026-18-3-8
REFERENCE:
1. Singh Malik D, Mital N, Kaur G. Topical drug delivery systems: a patent review. Expert Opin Ther Pat. 2016;26(2):213-28.
2. Mohammed BS, Al Gawhari FJ. Transethosomes: a novel transdermal drug delivery system for antifungal drugs. Int J Drug Deliv Technol. 2021; 11:238-43.
3. Honeywell-Nguyen PL, Bouwstra JA. Vesicles as a tool for transdermal and dermal delivery. Drug Discov Today Technol. 2005; 2(1): 67-74.
4. Dhopavkar S, Kadu P. Transferosomes – a boon for transdermal delivery. Indo Am J Pharm Sci. 2017;4(9):2908-19.
5. Mbah CC, Builders PF, Attama AA. Nano vesicular carriers as alternative drug delivery systems: ethosomes in focus. Expert Opin Drug Deliv. 2014; 11(1): 45-59.
6. Samad A, Sultana Y, Aqil M. Liposomal drug delivery systems: an update review. Curr Drug Deliv. 2007; 4(4): 297-305.
7. Ali J, Raza R, Ameen S, Arshad A, Karim F, Akram MW, Shakir L. Transethosomes: a breakthrough system for transdermal and topical drug delivery. Pak Biomed J. 2022; 5:354-57.
8. Kalra N, Choudhary S, Arora P, Arora N. Ethosomal drug delivery system: a newer approach. Asian J Pharm.
9. Pooja H, Gopinath E, Chethan K, Ganesh NS, Vineeth Chandy. Transethosomes: an effective tool in bypassing barriers for topical administration formulation. Int J Creat Res Thoughts. 2023; 11(5): 921-33.
10. Bajaj KJ, Parab BS, Shidhaye SS. Nano-transethosomes: a novel tool for drug delivery through skin. Indian J Pharm Educ Res. 2021; 55(1): 1-10.
11. Dehaghani MZ, Mahapatra D, Joseph T. Novel vesicular system: an overview. J Appl Pharm Sci. 2021; 11(8)
12. Nayak D, Tippavajhala VK. A comprehensive review on preparation, evaluation and applications of deformable liposomes. Iran J Pharm Res. 2021; 20(1): 186-205.
13. Jadhav SM, Morey P, Karpe MM, Kadam V. Novel vesicular system: an overview. J Appl Pharm Sci. 2012; 2(1): 193-202.
14. Hassan AS, Hofni A, Abourehab MA, Abdel-Rahman IA. Ginger extract–loaded transethosomes for effective transdermal permeation and anti-inflammation in rat model. Int J Nanomedicine. 2023; 18:1259-80.
15. Lohumi A. A novel drug delivery system: niosomes review. J Drug Deliv Ther. 2012; 2(5):
16. Chandu VP, Arunachalam A, Jagannath S, Yamini K, Tharangini K, Chaitanya G. Niosomes: a novel drug delivery system. Int J Nov Trends Pharm Sci. 2012; 2(1): 25-31.
17. Sudheer P, Kaushik K. Review on niosomes – a novel approach for drug targeting. J Pharm Res. 2015; 14(1): 20-5.
18. Raj BS, Punitha IS, Dube S. Formulation and characterization of fast disintegrating tablets of amlodipine using super-disintegrants. J Appl Pharm Sci. 2012; 2(8): 118-23.
19. Acharya A, Goudanavar P, Joshi V. Development and characterization of prolonged release timolol maleate cubosomal gel for ocular drug delivery. Adv Pharm J. 2019; 4: 1-4.
20. Bhura MR, Bhagat KA, Shah SK. Formulation and evaluation of topical nano emulgel of adapalene. World J Pharm Sci. 2015; 3: 1013-24.
21. Verma NK, Singh AK, Mall PC, Yadav V, Jaiswal R. Ethosomal drug delivery system: a novel approach to transdermal drug delivery – a review. 2020; 2(4): 94-100.
22. Nicolini C. Ethanol based vesicular carriers in transdermal drug delivery: nanoethosomes and transethosomes in focus. Nanoworld J. 2016;1(2):
23. Walve JR, Bakliwal SR, Rane BR, Pawar SP. Transfersomes: a surrogated carrier for transdermal drug delivery system. Int J Appl Biol Pharm Technol. 2011; 2(1):