Author(s):
Pratik Terse, Sandesh Chede, Trupti Mestry, Siddhi Shivade
Email(s):
spscobp03@gmail.com
DOI:
10.52711/0975-4377.2026.00016 
Address:
Pratik Terse*, Sandesh Chede, Trupti Mestry, Siddhi Shivade
Shree Pushpasen Sawant College of Pharmacy, Kudal, 416521 Maharashtra, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 2,
Year - 2026
ABSTRACT:
This study involves the development and assessment of a herbal toothpaste that uses natural ingredients that benefit oral health. The formulation uses Babul leaf powder, clove oil, Tulsi oil, honey, and camphor as antibacterial, antiseptic, and anti-inflammatory herbal ingredients. A total of nine batches (F1–F9) were prepared and assessed using a factorial design for the pH, abrasiveness, foam and spreadability, extrudability, homogeneity, moisture content, and antimicrobial activity for the biological and physicochemical criteria. The pH of the formulations ranges from 7.04 to 7.89, indicating that the formulation is neutral to mildly alkaline, which is ideal for promoting oral health and preventing enamel erosion. The foam and spreadability were optimal, which contribute to the ease of application and overall satisfaction from the user. For the antimicrobial activity against Staphylococcus aureus, the batches F6 and F8 were the most notable, with inhibition of 25 mm and 22 mm, respectively. F8 is the most balanced in physicochemical and antimicrobial activity, which is why it was selected as the optimized formulation. These results show that the herbal ingredients, clove oil, Tulsi, and babul, indicated that they can replace the synthetic chemicals used in toothpaste.
Cite this article:
Pratik Terse, Sandesh Chede, Trupti Mestry, Siddhi Shivade. Formulation and Evaluation of an Antimicrobial Toothpaste for Oral Health. Research Journal of Pharmaceutical Dosage Forms and Technology. 2026; 18(2):101-7. doi: 10.52711/0975-4377.2026.00016
Cite(Electronic):
Pratik Terse, Sandesh Chede, Trupti Mestry, Siddhi Shivade. Formulation and Evaluation of an Antimicrobial Toothpaste for Oral Health. Research Journal of Pharmaceutical Dosage Forms and Technology. 2026; 18(2):101-7. doi: 10.52711/0975-4377.2026.00016 Available on: https://www.rjpdft.com/AbstractView.aspx?PID=2026-18-2-2
REFERENCE:
1. Rathi NM, Sirsat SV, Toshniwal SS, Zagare NT, Shaikh Mahamad SF. Formulation and evaluation study on herbal toothpaste: a review. Int J Novel Res Dev. 2022; 7(4): 968–74.
2. Sahani DS, Sherkar M, Shirsath D, Wamane V, Gaikwad V. A research on: formulation and evaluation of herbal toothpaste. J Emerg Technol Innov Res.
3. Danavale NP, Shivtar NK, Sonawane RA. Review on herbal toothpaste. Int J Adv Res Sci Commun Technol (IJARSCT).
4. Senthilkumar KL, Venkateswaran S, Vasanthan A, Chiranjeevi P, Mohamed N, Dinesh S, et al. Formulation development and evaluation of novel herbal toothpaste from natural source. Int J Pharm Chem Anal.
5. Srivastava S, Bansal PK, Fatima A, Ahmad A, Ali A, Pathan A. A review on toothpaste to treat sensitive teeth. World J Pharm Res.
6. Nagansurkar SB, Bhosale SK, Deshmukh SD. Preparation and evaluation of herbal toothpaste. Int J Adv Res Sci Commun Technol.
7. Rajale PA, Gaikwad V. Herbal toothpaste. JETIR. 2024; 11(6).
8. Sekar M, Sridevi NJ, Aravind A. Formulation, evaluation and antibacterial properties of novel polyherbal toothpaste for oral care. Int J Pharm Clin Res.
9. Kanoja AP, Gajbhiye PV, Bhoyar PB, Jaiswal HA. To formulate and evaluate herbal toothpaste. Int J Pharm Sci.
10. Yadav K, Prakash S. Dental caries: a review. Asian J Biomed Pharm Sci. 2016
11. Pawar SS, Bhokare SK, Thombre KS. Preparation and evaluations of herbal toothpaste. World J Pharm Pharm Sci.
12. Bharwal A, Kapila I, Lata S, Arora A, Abbot V. Unveiling herbal dentifrices: A comprehensive review of natural oral hygiene solutions. Next Research.
13. Shahidulla D, Begum N, Sultana N. Herbal toothpaste: an overview. Int J Novel Res Dev
14. Solanke RB, Bhutada MD, Raut GM. Formulation and evaluation of herbal toothpaste. Int J Res Dev.
15. Mulla N, Bhosale SK, Yadav PY. Herbal toothpaste for antibacterial activity: a review. World J Pharm Pharm Sci.