Author(s):
Hritik Sahu, Purvi Yadav, Anju Mishra, Geetanjali Sahu, Anish Chandy
Email(s):
anishpharma@gmail.com
DOI:
10.52711/0975-4377.2026.00003 
Address:
Hritik Sahu1, Purvi Yadav1, Anju Mishra2, Geetanjali Sahu2, Anish Chandy3
1Students, School of Pharmacy, Chouksey Engineering College, Bilaspur (CG) India.
2Assistant Professor, School of Pharmacy, Chouksey Engineering College, Bilaspur (CG).
3Associate Professor, School of Pharmacy, Chouksey Engineering College, Bilaspur (CG).
*Corresponding Author
Published In:
Volume - 18,
Issue - 1,
Year - 2026
ABSTRACT:
The aim of the research was to design and test Itraconazole loaded nanoparticles drug delivery system, as the Itraconazole nanoparticles of appropriate size ranges are likely to enhance the therapeutic and toxicity reduction effects of this wide-spectrum antifungal agent. The loading of Itraconazole nanoparticles was done through Emulsification and Solvent Evaporation. Optimized ratios of excipients were also conducted in which the ratio of drugs-lipid and the ratio, surfactant-cosurfactant (Km) were adjusted to optimize the formulation properties. The zeta potential measurement and the analysis of the particle size were performed using Malvern Mastersizer Hydro 2000G. The in vitro release profile of nanoparticles showed to have a maximum release profile of 12h. The nanoparticle preparation methodology was a microemulsion mediated process that included high drug loading (ca. 80%), low and narrow size distribution and offered a reproducible and a rapid method of production. The article expounds the viability and the appropriateness of lipid based colloidal drug delivery system, using optimize design to create a clinically beneficial nanoparticle system, having targeting capabilities.
Cite this article:
Hritik Sahu, Purvi Yadav, Anju Mishra, Geetanjali Sahu, Anish Chandy. Fabrication and Evaluation of Itraconazole Particulate Drug Delivery System. Research Journal of Pharmaceutical Dosage Forms and Technology.2026; 18(1):17-2. doi: 10.52711/0975-4377.2026.00003
Cite(Electronic):
Hritik Sahu, Purvi Yadav, Anju Mishra, Geetanjali Sahu, Anish Chandy. Fabrication and Evaluation of Itraconazole Particulate Drug Delivery System. Research Journal of Pharmaceutical Dosage Forms and Technology.2026; 18(1):17-2. doi: 10.52711/0975-4377.2026.00003 Available on: https://www.rjpdft.com/AbstractView.aspx?PID=2026-18-1-3
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