ABSTRACT:
The present research focuses on developing a tablet-in-tablet dosage form containing Flunarizine HCl to provide both immediate and sustained drug release in a single unit. Flunarizine HCl is a poorly water-soluble drug primarily used for migraine treatment. In this study, the inner core tablet was designed for sustained release using HPMC K4M and Eudragit RS 100, while the outer shell was designed for immediate release using Crospovidone and MCC. The effects of important excipients on drug release and assay were investigated in order to optimize the formulation using a 2² factorial approach. Pre- and post-compression properties such as strength, thickness, flexibility, moisture level, FTIR compatibility, DSC thermograms, and the formulations' in vitro drug release were evaluated. batch that was optimized had favourable physical characteristics, consistent drug content, and appropriate release profiles. According to the study's findings, the tablet-in-tablet method shows promise in producing modulated release and enhancing patient adherence for long-term illnesses like migraines.
Cite this article:
Akshay H. Aher, Rajendra K. Surawase. Formulation Development and Evaluation of Flunarizine HCl Tablet by using Tablet in Tablet Technique. Research Journal of Pharmaceutical Dosage Forms and Technology. 2025; 17(4):247-6. doi: 10.52711/0975-4377.2025.00034
Cite(Electronic):
Akshay H. Aher, Rajendra K. Surawase. Formulation Development and Evaluation of Flunarizine HCl Tablet by using Tablet in Tablet Technique. Research Journal of Pharmaceutical Dosage Forms and Technology. 2025; 17(4):247-6. doi: 10.52711/0975-4377.2025.00034 Available on: https://www.rjpdft.com/AbstractView.aspx?PID=2025-17-4-4
REFERENCES:
1. Aher Akshay H, Rajendra K. Surawase, Wagh Rakesh M, Khairnar Darshan B, Gangurde Lalit H, Review on Tablet in Tablet Techniques. 2025; 7(20: 13.
2. Gaikwad and Kshirsagar Beni. Review on Tablet in Tablet techniques. Suef University Journal of Basic and Applied Sciences. 2020; 9: 1 https://doi.org/10.1186/s43088-019-0027-7
3. Mehta Bansari, Jigar Vyas and Umesh Upadhyay. A concise review on tablet in tablet. National Journal of Pharmaceutical Sciences. 2022; 2(2): 43-53
4. Shabana Naz Shah, Huma Ali, Riffat Yasmin, Shaheen Perveen, Farya Zafar, Fozia Israr, Nousheen Aslam. Design and optimization studies of tablet in tablet formulation of Diclofenac and misoprostol. https://doi.org/10.1101/2022.11.04.515246
5. Tejaswi Santosh Ubhe, Preeti Gedam. A Brief Overview on Tablet and It’s Types. Journal of Advancement in Pharmacology. 2020; 1(1): 21–31.
6. Nilottama S. Gundgal. A review: novel solventless coating techniques for tablet dosage form. 2013; 1(4): 60-66
7. Nadim Khan, Shubhangi Zende, Nishant Vairage, Saurabh Waghe, Satyam Ukarinde, Shubham Waghmare. Compression coating technique: A Review. International Journal of Humanities Social Science and Management (IJHSSM). 2023; 3(2): 596-601.
8. Rohit Pawar. Compression coated tablets as drug delivery system (tablet in tablet): A review. 2014; 6(1): 21 - 33.
9. Jyoti Mittha, Bhavana Habib. UV Spectrophotometric Method Development and Validation of Dasatinib in Bulk and Formulation. Asian Journal of Pharmaceutical Analysis. 2021; 11(3): 203-6.
10. Duggi Adilakshmi, Abdul Saleem Mohammad, Nuha Rasheed, Kathula Umadevi, Chandana Pasupuleti. Simultaneous Formulation, Estimation and Evaluation of Allopurinol Sustained Release Tablets using various suitable Excipients. Asian J. Pharm. Ana. 2016; 6(3): 155-166.
11. Noorussaba, Afaq Ahmad. Synthesis, Infrared spectroscopic and Thermal studies of [0.7(Cu2CdI4):0.3(AgIx: CuI(1-x))] of fast-ion conductor (x = 0.2, 0.4, 0.6 and 0.8 mol. wt. %). Asian J. Research Chem. 2015; 8(2): 131-140.
12. Monica RP Rao, Devidas G Bachhav, Ramdas B Rode, Komal R Nikam, Namrata D Pathade. Compatibility Study of Aceclofenac and Tablet Disintegrants by Thermal and Nonthermal Methods. Research J. Pharm. and Tech. 2011; 4(3): 423-427.
13. N. Sravanthi, K. Alekhya, S. Punitha. Formulation and Process Scale up of Misoprostol Tablets. Research J. Pharm. and Tech. 2011; 4(11): 1673-1675.
14. Vinay R. Kothawade, Yashpal M. More, Pallavi P. Ahire. Development and Evaluation of Bilayer Tablets of Bimodal release of Bisoprolol Fumarate. Research Journal of Pharmaceutical Dosage Forms and Technology. 2024; 16(4): 309-6.
15. Vishal Kumar, Attish Bhardwaj, Navdeep Singh1, Kamya Goyal, Shammy Jindal. A Review on Tablet Dosage Form: Recent Advancements with Special Emphasis on Rapid Disintegrating Tablet. Asian Journal of Research in Pharmaceutical Sciences. 2021; 11(3): 237-246.
16. Nishanth I., Elango K., Deattu N., Stephen P. Formulation Development and Evaluation of Bilayer Tablets of Telmisartan for Immediate Release and Metformin Hydrochloride for Sustained Release. Research J. Pharma. Dosage Forms and Tech. 2013; 5(3): 139-144.
17. Shyamaladevi D., S. Suresh Kumar. Formulation and Evaluation of Bilayer Tablets of Montelukast Sodium Immediate Release and Doxofylline Sustained Release. Research J. Pharm. and Tech. 2013; 6(12): 1370-1374.
18. Bipin Gandhi, Ajay Bhagwat, Swarup Matkar, Anant Kuchik, Tejal Wale, Onkar Kokane, Nitin Rode. Formulation and Evaluation of Bilayer Tablets of Atenolol and Amlodipine for the Treatment of Hypertension. Research Journal of Pharmacy and Technology. 2025; 18(5): 2037-2.
19. Shital Dhuppe, S.S. Mitkare, D.M. Sakarkar. Recent techniques of pharmaceutical solventless coating: A review. 2012; 3(7).
20. Ms. Nandini D. Banerjee, Mrs. Sushma R. Singh. Formulation And Evaluation of Compression Coated Tablets of Cefpodoxime Proxetil. International Journal of Pharma Sciences and Research (IJPSR). 2013; 4(7).
21. Sunirmal Bhattacharjee, Beduin Mahanti, Kaustav Dasgupta. Solventless coating for tablet: A technical review. www.wjpps.com. 2016; 5(8): 485-500. 10.20959/wjpps20168-7385.
22. Pallavi. K, B. Gayathri, K. Chandralekha, K. Tejaswi. Solventless Coating - A Pliable Technique for future Coating Prospects. Pharma Times. 2015; 47(12). https://www.researchgate.net/publication/284726017.
23. Herbert A. Lieberman, Leon Lachman, Joseph B. Schwartz. Pharmaceutical Dosage Forms: Tablets, Second Edition, revised and expanded. Marcel Dekker, INC.