Author(s):
Khateshwar Singh, Manali Rai, Saket Singh Chandel, Neelima Yadav, Aayush Vaishnaw
Email(s):
singhpharma@gmail.com
DOI:
10.52711/0975-4377.2025.00033 
Address:
Khateshwar Singh1, Manali Rai2, Saket Singh Chandel2*, Neelima Yadav2, Aayush Vaishnaw2
1Research Scholar, Department of Pharmaceutics, Dr. C.V. Raman Institute of Pharmacy, Dr. C.V. Raman University, Kota, Bilaspur, Chhattisgarh - 495113, India.
2Faculty of Pharmacy, Dr. C.V. Raman Institute of Pharmacy, Dr. C.V. Raman University, Kota, Bilaspur, Chhattisgarh - 495113, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 4,
Year - 2025
ABSTRACT:
A topical imidazole antifungal medication with broad-spectrum action is luliconazole. Nevertheless, it faces difficulties such as poor penetration, skin retention, and aqueous solubility, which lower its cutaneous bioavailability and impair its effectiveness in drug delivery. Formulating and characterizing luliconazole-loaded nanostructured lipid carriers for topical fungal infections was the goal of the current investigation. A modified solvent diffusion approach was used to produce the LCZ-SLNs following preformulation investigations. Key parameters such as poly-dispersity index (PDI), zeta potential, encapsulation efficiency (EE%), and Fourier transform infrared (FTIR) analysis were assessed during the characterization process. In vitro drug release kinetics were also examined. The results indicated that LCZ-SLNs exhibited favorable zeta potential, homogeneous dispersion, and nanoscale dimensions. The encapsulation efficiency of LCZ in SLNs was nearly 90%. FTIR analysis revealed no chemical interactions between LCZ and excipients. In vitro drug release tests showed that LCZ-SLNs substantially enhanced the drug's dissolution rate. Stability testing demonstrated consistent colloidal nanometer sizes in the LCZ-SLNs samples. The study suggests that the LCZ-SLNs formulation could be a promising option for topical treatment of superficial fungal infections.
Cite this article:
Khateshwar Singh, Manali Rai, Saket Singh Chandel, Neelima Yadav, Aayush Vaishnaw. Evaluation of Formulated Luliconazole Lipid Nano Particle Gel Targeting Topical Fungal Infections. Research Journal of Pharmaceutical Dosage Forms and Technology. 2025; 17(4):239-6. doi: 10.52711/0975-4377.2025.00033
Cite(Electronic):
Khateshwar Singh, Manali Rai, Saket Singh Chandel, Neelima Yadav, Aayush Vaishnaw. Evaluation of Formulated Luliconazole Lipid Nano Particle Gel Targeting Topical Fungal Infections. Research Journal of Pharmaceutical Dosage Forms and Technology. 2025; 17(4):239-6. doi: 10.52711/0975-4377.2025.00033 Available on: https://www.rjpdft.com/AbstractView.aspx?PID=2025-17-4-3
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