Development and Evaluation of Gastroretentive Floating Tablets of Nizatidine based on Effervescent Technology

Y. Krishna Reddy; Faria Tahseen

doi:10.5958/0975-4377.2020.00017.8

Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)

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Development and Evaluation of Gastroretentive Floating Tablets of Nizatidine based on Effervescent Technology

Author(s): Y. Krishna Reddy, Faria Tahseen

Email(s): rajinisuralabs1@gmail.com

DOI: 10.5958/0975-4377.2020.00017.8

Address: Dr. Y. Krishna Reddy*, Faria Tahseen
Department of Pharmaceutics, Nalanda College of Pharmacy, Jawaharlal Nehru Technological University, Hyderabad, Telangana.
*Corresponding Author

Published In: Volume - 12, Issue - 2, Year - 2020

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ABSTRACT:
In the present research work gastro retentive floating matrix formulation of Nizatidine by using various polymers were developed. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimised. Then the formulation was developed by using different concentrations of polymers Amla extract, Ginger extract, Fenugreek extract, Isapgol husk as polymeric substances. The formulation blend was subjected to various preformualation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations the formulations Amla extract as polymer were retarded the drug release more than12 hours (F3=98.73%). whereas in low concentrations the polymer was unable to produce the desired action. The optimised formulation dissolution data was subjected to release kinetics, from the release kinetics data it was evident that the formulation followed peppas release kinetics mechanism of drug release.

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Cite this article:
Y. Krishna Reddy, Faria Tahseen. Development and Evaluation of Gastroretentive Floating Tablets of Nizatidine based on Effervescent Technology. Res. J. Pharma. Dosage Forms and Tech.2020; 12(2): 93-97. doi: 10.5958/0975-4377.2020.00017.8

Cite(Electronic):
Y. Krishna Reddy, Faria Tahseen. Development and Evaluation of Gastroretentive Floating Tablets of Nizatidine based on Effervescent Technology. Res. J. Pharma. Dosage Forms and Tech.2020; 12(2): 93-97. doi: 10.5958/0975-4377.2020.00017.8 Available on: https://www.rjpdft.com/AbstractView.aspx?PID=2020-12-2-11

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DOI: 10.5958/0975-4377