Recent trends in role of superdisintegrants to formulation of solid oral dosage form

Debjit Bhowmik; Rishab Bhanot; K.P. Sampath Kumar

doi:10.5958/0975-4377.2018.00036.8

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

Submit Article

Recent trends in role of superdisintegrants to formulation of solid oral dosage form

Author(s): Debjit Bhowmik, Rishab Bhanot, K.P. Sampath Kumar

Email(s): debjit_cr@yahoo.com

DOI: 10.5958/0975-4377.2018.00036.8

Address: Debjit Bhowmik1*, Rishab Bhanot1, K.P. Sampath Kumar2
1Himachal Institute of Pharmaceutical Education and Research, Nadaun, Hamirpur, H.P.
2Department of Pharmacy, Coimbatore Government Medical College, Coimbatore
*Corresponding Author

Published In: Volume - 10, Issue - 4, Year - 2018

View HTML

View PDF

ABSTRACT:
Disintegrating agents are substances routinely included in the tablet formulations to aid in the break up of the compacted mass when it is put into a fluid environment. They promote moisture penetration and dispersion of the tablet matrix. In recent years, several newer agents have been developed known as “Superdisintegrants”. These newer substances are more effective at lower concentrations with greater disintegrating efficiency and mechanical strength. On contact with water the superdisintegrants swell, hydrate, change volume or form and produce a disruptive change in the tablet. Effective superdisintegrants provide improved compressibility, compatibility and have no negative impact on the mechanical strength of formulations containing high-dose drugs. The orally disintegrating tablet is a solid dosage form that disintegrates and dissolves in the mouth without the need of water within 60 seconds or less. According to the US Food and Drug Administration, orally disintegrating tablet is "a solid dosage form containing medicinal substances, which disintegrates rapidly, usually within a matter of seconds, when placed upon the tongue" By FDA guidance, orally disintegrating tablet should have an in vitro disintegration time of 30 seconds or less, based on the US Pharmacopeia disintegration test method.

Keywords:

Cite this article:
Debjit Bhowmik, Rishab Bhanot, K.P. Sampath Kumar. Recent trends in role of superdisintegrants to formulation of solid oral dosage form. Res. J. Pharm. Dosage Form. & Tech. 2018; 10(4): 245-252. doi: 10.5958/0975-4377.2018.00036.8

Cite(Electronic):
Debjit Bhowmik, Rishab Bhanot, K.P. Sampath Kumar. Recent trends in role of superdisintegrants to formulation of solid oral dosage form. Res. J. Pharm. Dosage Form. & Tech. 2018; 10(4): 245-252. doi: 10.5958/0975-4377.2018.00036.8 Available on: https://www.rjpdft.com/AbstractView.aspx?PID=2018-10-4-5

Recomonded Articles:

Formulation Development and Evaluation of Capsule Containing Fluclaxacillin Sodium and Amoxicillin Trihydrate with Enteric Coated Granules of Lactic Acid Bacillus

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI: Access: Open Access Read More

Formulation and Evaluation of Tolperisone Hydrochloride Sustained Release Tablet

Author(s): Domendra Sahu, Shekhar Verma , Ravindra D. Dubey

DOI: Access: Open Access Read More

Transdermal Drug Delivery System of Antidiabetic Drugs: A Review

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI: Access: Open Access Read More

Isolation and evaluation of Basella alba linn. Leaf mucilage as release retardant in tablet formulation

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4 Access: Open Access Read More

Review on Enteric Coated Polymers.

Author(s): Gayatri D. Patil, Kaveri P. Tambe, Sangita P. Shirsat, Paresh A. Patil

DOI: 10.5958/0975-4377.2021.00015.X Access: Open Access Read More

Self Microemulsifying Drug Delivery System (SMEDDS): A Novel Approach to Improve the Therapeutic Efficacy of Orally Administered Drug

Author(s): Kritika Kanoujia, Chandraprabha Dewangan, Ayushi Masih, Dipti Sinha, Divya Oraon, Manisha Jaiswal, Monika Sahu, Ranjeeta Kumari, Sapna Pradhan, Ravi Suman, Rajkishan Dewangan, Roman Banjare, Pradeep Paikra, Mukesh Rawtiya, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00015.0 Access: Open Access Read More

Formulation and Evaluation of Transdermal Patch of Aceclofenac

Author(s): Rakesh P. Patel, Grishma Patel, Hitesh Patel , Ashok Baria

DOI: Access: Open Access Read More

Formulation and Evaluation of Fast Dissolving Tablets of Trimetazidine Dihydrochloride Using Natural and Synthetic Superdisintegrants

Author(s): Simila Madathil, RaviKumar, Anju Govind, Mercy Mathew, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00013.6 Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available
DOI: 10.5958/0975-4377