Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)


Submit Article

Formulation and Evaluation of Extended Release Tablets of Alfuzosin Hydrochloride

Author(s): G. Nalini, V. Sai Kishore

Email(s): nalinigovada@gmail.com

DOI: Not Available

Address: G. Nalini* and V. Sai Kishore
Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla-522101.
*Corresponding Author

Published In:   Volume - 2,      Issue - 6,     Year - 2010

 View HTML        View PDF

ABSTRACT:
The purpose of this work was to develop extended-release matrix tablets of highly water-soluble alfuzosin hydrochloride using different viscosity grades of Hydrxy propyl methyl cellulose polymers by wet granulation method. The influence of three granulating fluids viz. water, dichloromethane: ethanol and isopropyl alcohol on release rate of alfuzosin hydrochloride were studied with a view to design and development of once daily formulations of alfuzosin hydrochloride. The tablets were analysed to determine their hardness, friability, drug content and an in vitro release study was carried out. The dissolution profile indicated that the drug release was found to be influenced by the polymer and granulating fluid employed in the formulation. Based on release rate the polymers can be rated as HPMC K100M > HPMC K15M> HPMC K4M. Based on the dissolution rate the granulating fluids can be rated as water>dichloromethane: ethanol> isopropyl alcohol. The dissolution profiles followed first order kinetics and the mechanism of drug release was governed by peppas model. The n values are found to be more than 0.5 (n>0.5) indicted that the drug release was predominantly controlled by non fickian diffusion. Thus this study clearly indicates that Alfuzosin hydrochloride tablets formulated with HPMC K100M polymer by employing water as granulating fluid is more suitable to design the extended release formulation of alfuzosin hydrochloride matrix tablets for 24 hours.


Keywords:

Cite this article:
G. Nalini, V. Sai Kishore. Formulation and Evaluation of Extended Release Tablets of Alfuzosin Hydrochloride. Research J. Pharma. Dosage Forms and Tech. 2010; 2(6): 384-387.

Cite(Electronic):
G. Nalini, V. Sai Kishore. Formulation and Evaluation of Extended Release Tablets of Alfuzosin Hydrochloride. Research J. Pharma. Dosage Forms and Tech. 2010; 2(6): 384-387.   Available on: https://www.rjpdft.com/AbstractView.aspx?PID=2010-2-6-7


Recomonded Articles:

Formulation Development and Evaluation of Sodium Valproate and Valproic acid Extended Release Tablets

Author(s): K. Vanitha, Prasanna Kumar Desu

DOI: 10.5958/0975-4377.2019.00012.0         Access: Open Access Read More

Formulation and Evaluation of Mucoadhesive Buccal Patch of Saxagliptin Hydrochloride

Author(s): Patil Namrata D., Gondkar S.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00033.1         Access: Open Access Read More

Extended Release Drug Delivery-An Effective Way of Novel Drug Delivery System

Author(s): Debjit Bhowmik, Rishab Bhanot, K.P. Sampath Kumar

DOI: 10.5958/0975-4377.2018.00035.6         Access: Open Access Read More

Development and Optimization of Floating Tablets Containing Rebamipide

Author(s): Jigar Vyas, Jai Mehta, Neha Pal, Kapil Daxini

DOI: 10.5958/0975-4377.2020.00002.6         Access: Open Access Read More

In-Vitro Release Kinetic Study of Mosapride Citrate Dihydrate from Sustained Release Matrix Tablet Containing Two Different Viscosity Grades of HPMC

Author(s): Sawant VA, Jayprabha P, Shende VS, Borkar SN, Wakale VS, Deore SR, Dame GY, Barve AO, Chatap VK

DOI:         Access: Open Access Read More

Formulation and Evaluation of Modified Pulsincap Drug Delivery System for Chronotherapeutic Delivery of Montelukast Sodium

Author(s): V. Kalyani, K. Basanthi , T.E.G.K. Murthy

DOI:         Access: Open Access Read More

Design and Evaluation of Sustained Release Matrix Tablets of Ibuprofen

Author(s): Amit K. Jain, Rajput Rammulrajsinh, Pradeep Agrawal, Kinal patel

DOI:         Access: Open Access Read More

Formulation and evaluation of colon specific tinidazole matrix tablets

Author(s): Asma Sulthana, B. Ramu, G. Srikanth, Bigala Rajkamal

DOI: 10.5958/0975-4377.2016.00022.7         Access: Open Access Read More

Formulation and Evaluation of Transdermal Patches of Nebivolol Hydrochloride

Author(s): Vijay Singh Jatav, Jitendra Singh Saggu, Ashish Kumar Sharma, Anil Sharma, Rakesh Kumar Jat

DOI:         Access: Open Access Read More

Design, Development and Evaluation of Pulsatile Drug Delivery System of Ramipril

Author(s): AL. Akilandeshwari , K. Elango, S. Daisy Chellakumari, S. Kishore Kumar

DOI:         Access: Open Access Read More

Formulation and Evaluation of Extended Release Tablets of Alfuzosin Hydrochloride

Author(s): G. Nalini, V. Sai Kishore

DOI:         Access: Open Access Read More

Formulation and Evaluation of Candesartan Microspheres

Author(s): B. Saraswathi, T. Satyanarayana, G. Manasa, Ch. Mounika, Md Sanakowsar, P. Gopi Chandh, K. Krishnaveni

DOI: 10.5958/0975-4377.2019.00013.2         Access: Open Access Read More

Design and Evaluation of Ranitidine Hydrochloride Floating Tablets for oral controlled release.

Author(s): Choudhury A, Dash SK , Roy A, Bahadur S, Saha S, Das S

DOI:         Access: Open Access Read More

Formulation and Evaluation of Atorvastatin Calcium Floating Tablets by using Xanthum Gum as a Release Modifying Agent

Author(s): Nitin Mogal, Snehal Kulkarni, Swapnil Deshpande, Pradnya Vishwe

DOI: 10.5958/0975-4377.2015.00036.1         Access: Open Access Read More

Development and Evaluation of Metoclopramide Hydrochloride Floating Microspheres for controlled Release

Author(s): Vaseeha Banu T. S1, Mohammad Sameer Ansari, Mohamed Khaleel

DOI: 10.5958/0975-4377.2019.00030.2         Access: Open Access Read More

Formulation and Evaluation of Floating Drug Delivery System of Antidiabetic Drug

Author(s): Rekha Hondadakatti, S. R. Iliger, Manjula Lagali

DOI: 10.52711/0975-4377.2021.00018         Access: Open Access Read More

Formulation and in vitro-in vivo Evaluation of Theophyline and Salbutamol Sulphate Sustained Release Tablets

Author(s): Prakash N Kendre, Syed N Lateef, Rahul K Godge, Mahendra A Giri, Bharat D Pagare , Ritesh D Patel

DOI:         Access: Open Access Read More

Design and In Vitro Studies of Ambroxol Hydrochloride Sustained Release Matrix Tablets.

Author(s): Shanmugam. S., Sandhiya. K. M., Ayyappan. T, Sundaramoorthy. K. , Vetrichelvan. T.

DOI:         Access: Open Access Read More

Formulation and In Vitro-In Vivo Evaluation of Alfuzosin Hydrochloride Floating Matrix Tablets

Author(s): Rahul K Godge, Stephen L Fernandes, Syed N Lateef, Abhijeet N Merekar, Prakash N Kendre

DOI:         Access: Open Access Read More

Formulation and Evaluation of Sustained Release Matrix Tablet of Valsartan

Author(s): Sandesh Y. Pawar, Rajendra K. Surawase.

DOI: 10.52711/0975-4377.2023.00039         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 

Quick Links


Latest Issues

Popular Articles


Recent Articles



Study of effect of Muco Adhesive Polymers on Domperidone Hard Candy Lozenges
Formulation and Evaluation of In-Situ Gel for the Treatment of Wet Age-Related Macular Degeneration
Technique to Formulation of Amorphous Drug
Development of Combinatorial Aqueous Herbal Extract Loaded Orodispersible Tablets for the Prevention and Treatment of COVID-19
Evaluation of Formulated Luliconazole Lipid Nano Particle Gel Targeting Topical Fungal Infections
Formulation Development and Evaluation of Flunarizine HCl Tablet by using Tablet in Tablet Technique
Simultaneous Estimation of Tolperisone and Etoricoxib in Bulk and Tablet Dosage Form by Spectrophotometric Methods
Development and Evaluation of Mucoadhesive Buccal Films of Lacidipine Utilizing Sterculia foetida Gum as a Natural Polymer
Development of effective Herbal-based Ketoprofen Transdermal patch for pain management
Crispr-Based Drug Delivery and Therapeutics in Gene Therapy: A Comprehensive Review
Silver Nanoparticles: A Comprehensive Review on Synthesis, Properties and Applications
Formulation and Evaluation of a Hibiscus-Based Herbal Gel for the Treatment of Mouth Ulcers
Formulation and Evaluation of Ophthalmic Self Emulsifying Drug Delivery System of Ketoconazole
Formulation and Characterization of Polymeric Microspheres Loaded with Sesamol for Improving Bioavailability
Formulation and Development of Sustained Release Matrix Tablets of Ambroxol hydrochloride by QBD Approach
Preliminary Phytochemical Analysis of Punica granatum L. and its Therapeutic Implications
Microspheres in Modern Pharmaceutics: A Comprehensive Review of Types, Techniques, and Advancements
Quality by Design (QBD) in Pharmaceutical Development: A Review of Principles and Case Studies
A Review of Pulsatile Drug Delivery Systems
Development and Evaluation of Sublingual Tablet of Lercanidipine by Solid Dispersion Method

Tags


About Journal

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. The aim of RJPDFT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPDFT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical Chemistry, Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
Read More  

Visitors

Today: 1597
Yesterday: 3032
Total: 1450736